Ferrer cruised past Mikhail Kukushkin of Kazakhstan 6-2, 6-3 in the opening round of the clay tournament in Acapulco, but Murray needed three sets to get past Pablo Andujar 3-6, 6-1, 6-2.
Fourth-seeded Grigor Dimitrov of Bulgaria eliminated Australian qualifier Marinko Matosevic 7-5, 6-1. Fifth-seeded Kevin Anderson of South Africa battled past Stephane Robert of France 6-2, 7-6 (9-7).
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