Irving netted 14 of his total in the fourth quarter as the Cavs dealt the Thunder a third consecutive home loss.
Tristan Thompson had a double-double of 11 points and 11 rebounds.
Kevin Durant recorded 28 points, 10 rebounds and nine assists, but it wasn't enough to prevent the Thunder's longest home skid since 2009.
Russell Westbrook supplied 24 points and nine assists for Oklahoma City.
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