Nadal set down his Ukrainian opponent 6-3, 7-6 (7-3) on the clay courts of the Jockey Club Brasileiro to claim a victory in the inaugural Rio de Janeiro event.
The top-ranked Spaniard added the Rio title to his win last month in Qatar. He also reached the final of the Australian Open before falling to Stanislas Wawrinka.
The 54-ranked Dolgopolov came up short in his bid for a third career ATP singles title, falling to 0-5 lifetime against Nadal.
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