Kemba Walker dished off a personal-best 16 assists to go with 24 points for the Bobcats, who established a 2 1/2-game lead over the Pistons for the Eastern Conference's eighth playoff spot.
Josh McRoberts totaled 15 points, five rebounds and five assists.
Gerald Henderson and Michael Kidd-Gilchrist netted 11 points each for Charlotte.
The Pistons were led by Brandon Jennings with 20 points.
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