Parker, who played just 11 minutes in Sunday's NBA All-Star Game, is suffering from "a variety of maladies" and will need time to recover, the coach said.
"He doesn't have a pulled hamstring or anything, but he's got a lot of little things," Popovich said. "Basically a lot of basketball the last three years, all season long, all summer long."
Parker, averaging 17.7 points and 6.2 assists per game through 47 contests this season, sat out the Spurs' final game before the break with a sore lower back.
Celebrity Families of 2014 [PHOTOS]