All-Star Game MVP Kyrie Irving had 14 points and Luol Deng helped out with 13 for the Cavaliers, who jumped out to an 18-8 lead and never looked back en route to a fifth straight win.
Tristan Thompson (12 points, 10 rebounds) and Anthony Bennett (10, 11) each provided a double-double.
Michael-Carter Williams and Thaddeus Young netted 15 apiece for the lowly 76ers, who dropped an eighth straight at home and ninth straight overall.
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