All-Star Game MVP Kyrie Irving had 14 points and Luol Deng helped out with 13 for the Cavaliers, who jumped out to an 18-8 lead and never looked back en route to a fifth straight win.
Tristan Thompson (12 points, 10 rebounds) and Anthony Bennett (10, 11) each provided a double-double.
Michael-Carter Williams and Thaddeus Young netted 15 apiece for the lowly 76ers, who dropped an eighth straight at home and ninth straight overall.
Pregnant Mila Kunis wins 'Best Villain' at MTV Movie Awards
Charlize Theron not engaged to Sean Penn 'yet'