Griffin was a workhorse Wednesday, going 13-for-21 and playing 39 minutes, 15 seconds in the Clippers' third consecutive win.
LaMarcus Aldridge led Portland with 25 points. Damian Lillard scored 21. The Trail Blazers lost for the sixth time in their last nine games.
Aldridge cut the Clippers' lead to 118-117 with a layup with 2:01 left in the game, but DeAndre Jordan's dunk with 1:25 left and two subsequent free throws by Crawford fended off the rally.