Randolph pumped in 20 points and Lee added 17 as Memphis claimed a third win in four games.
Nikola Vucevic posted a double-double of 13 points and 10 rebounds for the Magic, which fell for first time in four contests.
Tobias Harris (13 points, seven rebounds), Glen Davis (12 points) and Arron Afflalo (10) also reached double figures.
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