Griffin, who also carded 11 rebounds and six assists, had a pair of spectacular windmill slams, each assisted by Chris Paul -- who supplied seven points and eight assists in his return from an 18-game injury absence -- as the Clippers smashed a club record for the largest margin of victory at 45 points.
Their previous mark was a 39-point win over the Chicago Bulls in November.
Jamal Crawford added 21 points for Los Angeles, which jumped out to a 13-0 lead and never looked back.
The Clippers ended an explosive first quarter with a 46-15 lead, then stretched their advantage to 39 points at the half and led by as many as 56 points, 89-33, with 6 minutes remaining in the third period.
Tony Wroten scored 21 points and Thaddeus Young totaled 15 with 11 rebounds for the 76ers, who dropped a sixth straight.
Philadelphia shot a paltry 27 percent from the field, including 3-of-28 from 3-point range.