The Spaniard dropped the first set but then rebounded for 3-6, 6-4, 6-4 win over German Julian Reister in Day 1 on the clay courts at Vina del Mar.
Also advancing Monday was Argentine Leonardo Mayer, who bested Austrian Andreas Haider-Maurer 7-5, 7-5.
His next opponent will be second-seeded Spaniard Tommy Robredo.
Notable deaths of 2014 [PHOTOS]
Michael Sam cut from the Dallas Cowboys