It was the 10th straight game with at least 30 points for Durant, who became the sixth player since 1990 to accomplish the feat.
Durant, averaging 38.7 points per game during the span, connected on 12-of-17 shots from the field after sitting out the Thunder's previous game with a shoulder injury.
Serge Ibaka added 25 points on 12-of-16 shooting with 11 rebounds and five blocked shots as Oklahoma City reeled off a seventh straight win.
James Anderson led the 76ers with 19 points and five rebounds.
Notable deaths of 2014 [PHOTOS]
LeBron James reveals his new Nike shoes