Ray Allen chipped in 12 points and nine rebounds as Miami notched a second straight following a three-game skid.
The Bobcats got 22 points and 14 rebounds from Al Jefferson.
Ramon Sessions notched 16 points and five assists for Charlotte, which lost for the fifth time in seven contests.
Bobcats guard Kemba Walker left in the third quarter with a sprained left ankle.
Rosie O'Donnell unveils nearly 50-pound weight loss
Iranian woman stops the execution of son's killer