Perreault scored the first goal of the game and then closed out the scoring in the third period with a late goal at 17:29 to nail down Anaheim's fourth straight victory.
Tuuka Rask allowed five goals on 30 shots in the loss. Daniel Paille and Dougie Hamilton tallied the two Boston goals.
The Bruins, who had won five of seven coming into the game, cut Anaheim's lead to 3-2 in the third period, but the Ducks responded with two late goals to put the game away.
Scarlett Johansson steps out with fiance after pregnancy reveal
Interpol investigating stolen passports on missing flight