The Hawks took advantage of Indiana's recently relentless schedule, one that saw the Pacers playing for the fourth time in five nights.
Indiana won the first three games in that stretch, but after traveling from Indianapolis following Tuesday's victory over Toronto the Pacers appeared to be out of gas.
Atlanta surrendered just 12 points in the first half, took a 19-point lead at halftime and held on to end a three-game losing streak. The Pacers lost for only the seventh time in 35 outings this year, still the fewest number of setbacks in the NBA.
Lance Stephenson was unable to play for the Pacers due to a knee injury he suffered on Tuesday. Paul George scored 28 points and seized 12 rebounds for Indiana.