Kevin Martin netted 18 points and Nikola Pekovic supplied a double-double of 16 and 14 rebounds as the Timberwolves rolled up a season-high point total.
Corey Brewer added 15 points and J.J. Barea provided 13 for Minnesota, which won a fourth in six games.
Dante Cunningham and Alexey Shved each scored 10 points.
The 76ers had their four-game winning streak snapped despite 20 points from Thaddeus Young.
James Anderson put in 14.