Lowry also had six assists in the victory, which extended Toronto's hot streak to five wins in their last six contests.
Toronto trailed 62-57 at the end of the third quarter but opened the final period with an 18-4 run that put them in the driver's seat. The Raptors outscored Chicago 28-17 in the fourth quarter.
Chicago, which has lost six of its last nine games, was led by Luol Deng's 16 points and 15 from Jimmy Butler.
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