Gerald Green connected on five 3-pointers to finish 21 points as the surging Suns racked up a 10th victory in 12 games.
Green got 14 of his total in the second quarter, igniting a decisive 16-4 run.
Channing Frye and P.J. Tucker and each netted 12 points for Phoenix.
Chris Paul was limited to 11 points with seven assists for the Clippers, who lost at home for just the third time in 16 games.