Johnson carried the ball 27 times and finished with at least 1,000 yards for a sixth straight year beginning his career. He became only the sixth player in NFL history to accomplish the feat.
Ryan Fitzpatrick connected on 15-of-24 passes for 166 yards with an interception for the Titans (7-9).
Matt Schaub went 22-for-34 through the air for 229 yards and two interceptions for Houston (2-14), which secured the NFL's first overall draft pick with the league's worst record.
Jonathan Grimes ran for 50 yards on 16 times in his first NFL start.
Celebrity Breakups and divorces of 2014 [PHOTOS]