Luck and Hilton hooked up 11 times, sparking a potent offense that boosted the Colts (11-5) to a one-sided victory in their last regular-season game of the year.
Luck made good on 26-of-37 passes with a score.
The Jaguars (4-12) were paced by Chad Henne, who finished 30-for-51 through the air for 331 yards, one touchdown and an interception.
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