Durant also distributed five assists and Jeremy Lamb scored 22 points off the bench as the NBA-best Thunder shot 57.3 percent from the floor in grabbing a 12th win in 13 games.
Reggie Jackson scored 16 points and handed out eight assists for Oklahoma City, which jumped out to a 13-0 lead and never trailed.
The Rockets were led by Aaron Brooks with 17 points.
Chandler Parsons and Omri Casspi added 15 apiece as the Rockets had their three-game win streak broken in resounding fashion.
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