Manu Ginobili came off the bench to pump in 18 points as San Antonio recorded a third win in four games.
Danny Green went 4-of-4 from 3-point range en route to 14 points and Kawhi Leonard supplied 13 and 10 rebounds.
Tim Duncan led the Spurs' rebounders with 12 boards.
Terrence Ross scored 23 points and Kyle Lowry also netted 23 with nine assists for Toronto, which lost for just the second time in six games.
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