Chris Paul provided 23 points, eight rebounds, seven assists and four steals for the Pacific Division-leading Clippers, who returned home after a long, seven-game road trip with a resounding win over the Southwest's top team.
Willie Green (11 points) drained a pair of 3-pointers to bookend a 19-0 run in the second period that vaulted Los Angeles into the lead for good. He finished 3-of-4 from 3-point range.
Tim Duncan had a double-double of 17 points and 11 rebounds for the Spurs, whose four-game winning streak was snapped.
Manu Ginobili contributed 16 off the bench.