Sherman and Maxwell each recorded two pick-offs of New York's Eli Manning, sparking a defensive effort that limited the Giants to just 181 yards.
Marshawn Lynch piled up 120 total yards with a touchdown as the Seahawks (12-2) moved closer to wrapping up home field advantage throughout the NFC playoffs.
Russell Wilson made good on 18-of-27 pass attempts for 206 yards with an interception and a touchdown.
Manning completed 18-of-31 passes en route to just 156 yards for New York (5-9), which was shut out at home in the regular season for the first time in 18 years.
NBC reportedly holds celebs hostage to Jimmy Fallon's show
Aaron Carter is still in love with Hilary Duff