Sherman and Maxwell each recorded two pick-offs of New York's Eli Manning, sparking a defensive effort that limited the Giants to just 181 yards.
Marshawn Lynch piled up 120 total yards with a touchdown as the Seahawks (12-2) moved closer to wrapping up home field advantage throughout the NFC playoffs.
Russell Wilson made good on 18-of-27 pass attempts for 206 yards with an interception and a touchdown.
Manning completed 18-of-31 passes en route to just 156 yards for New York (5-9), which was shut out at home in the regular season for the first time in 18 years.
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