Former 76er Dorell Wright (15 points) nailed 5-of-5 attempts from beyond the arc as the Trail Blazers knocked down 21 3-pointers overall, establishing a new team mark.
Nicolas Batum provided 17 points, nine assists and five rebounds and Damien Lillard drained 4-of-6 3-pointers en route to 16 points for Portland, which improved to 20-4 on the season.
Philadelphia, meanwhile, remained in a tailspin, dropping a sixth straight and 10th in 11 contests.
Tony Wroten led the Sixers with 18 points, seven assists and six rebounds.
Swim Week Miami Beach 2014 [PHOTOS]