Former 76er Dorell Wright (15 points) nailed 5-of-5 attempts from beyond the arc as the Trail Blazers knocked down 21 3-pointers overall, establishing a new team mark.
Nicolas Batum provided 17 points, nine assists and five rebounds and Damien Lillard drained 4-of-6 3-pointers en route to 16 points for Portland, which improved to 20-4 on the season.
Philadelphia, meanwhile, remained in a tailspin, dropping a sixth straight and 10th in 11 contests.
Tony Wroten led the Sixers with 18 points, seven assists and six rebounds.
Joan Rivers refuses to apologize for kidnapping joke
Avril Lavigne denies racism in 'Hello Kitty' music video