The Timberwolves overcame a 19-point deficit in the first half and defeated the 76ers for the fourth straight time, a first in franchise history.
Minnesota has won back-to-back games to get to the .500 mark.
Philadelphia was within two points when Love made a hook shot with 2:47 to play. His offensive rebound and tip-in with 1:09 left pushed the Timberwolves in front by six.
Ricky Rubio added 21 points and seven assists for Minnesota while Nikola Pekovic had 20 points and 10 rebounds.
Tony Wroten and Spencer Hawes both scored 20 points for the 76ers, who have lost four straight.