George provided 28 points with six assists. West provided 20 points and eight rebounds.
The Pacers, which won for the ninth time in 10 games overall, put the game away by outscoring San Antonio 67-37 in the second and third quarters, draining 9-of-11 three-pointers for the game.
San Antonio was led by Kawhi Leonard's 18 points.
Swim Week Miami Beach 2014 [PHOTOS]