Huberdeau's goal 3:29 into the final period snapped a 1-1 tie and gave the Panthers their first regulation victory over the Red Wings since Dec. 1, 1996 -- a span of 18 games.
During that time, Florida went 0-11-2 with five ties.
Jimmy Hayes also scored and Shawn Matthias added two assists as the Panthers won a second straight overall.
Tim Thomas made 22 saves.
Danny Cleary scored and Jonas Gustavsson stopped 35 shots for the Red Wings.