Crawford made 9-of-13 shots from the field and scored 22 points as part of the fifth Boston win in seven games.
The Celtics owned a 39-15 lead after one period and their lead grew to as many as 27 points in the first half.
Denver fought back to within 74-71 late in the third quarter, but came no closer after Boston put together a 9-2 run.
Ty Lawson led Denver with 20 points, but left late in the contest with a strained left hamstring. The Nuggets have lost two straight after winning seven in a row.