Wilson completed 22-of-30 throws and ran the ball eight times for 47 yards as the NFL-best Seahawks extended their home winning streak to 14 straight games.
Seattle yielded just 188 total yards to the Saints' high-powered offense.
Drew Brees was limited to 143 aerial yards with a touchdown on 23-of-38 efficiency in his worst performance since 2003 as New Orleans (9-3) had its three-game winning streak snapped.
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