George put in 27 points and West contributed 24 with 12 rebounds for the Pacers, who dealt the Clippers just their second home loss of the season.
Los Angeles had pulled to within 102-100 in the closing moments, but the Pacers dominated the offensive boards down the stretch to hang on for the win.
Jamal Crawford came off the bench to score 20 points for Los Angeles.
Chris Paul provided 17 points and 10 assists for the Lakers.
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