Lopez finished with 20 points and hauled down nine rebounds for the Nets, who improved to 2-7 in their last nine games.
Joe Johnson scored 26 points and Andray Blatche added 21.
Quincy Pondexter provided 22 points -- including 20 late in the game -- but it wasn't enough to rally the Grizzlies.
Mike Conley scored 16 and distributed 10 assists as Memphis fell for the third time in four games.
Swim Week Miami Beach 2014 [PHOTOS]