Lopez finished with 20 points and hauled down nine rebounds for the Nets, who improved to 2-7 in their last nine games.
Joe Johnson scored 26 points and Andray Blatche added 21.
Quincy Pondexter provided 22 points -- including 20 late in the game -- but it wasn't enough to rally the Grizzlies.
Mike Conley scored 16 and distributed 10 assists as Memphis fell for the third time in four games.
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