The Canucks produced four goals in the second period while snapping a two-game skid.
Sedin's goal came 31 seconds into the middle stanza and Booth then put a slap shot past Craig Anderson.
Jason Garrison and Dale Weise added goals in the second period, driving Anderson from the game. Anderson allowed the four goals on just 15 shots, after which Robin Lehner surrendered one goal over the final 30 minutes.
Roberto Luongo, meanwhile, made 37 saves to get the win.