It was the seventh straight loss for the Knicks, who have just three wins in 14 outings this season.
Chris Paul contributed 15 points and seven assists for the Clippers before leaving the game with a strained right hamstring. It was the third straight win for the Clippers and their eighth in 10 games.
Carmelo Anthony led the Knicks with 27 points and nine rebounds. New York made only 38 percent of its shots from the field and hit on just 3-of-20 from 3-point range.