George also provided eight rebounds, four steals and four assists as Indiana ran its home unbeaten streak to eight games starting the season.
Hill contributed seven assists and five steals for the Pacers, who broke the game open with a 17-5 run early in the fourth quarter.
The Timberwolves lost for the fourth time in five games despite 20 points and 17 from Kevin Love.
Nikola Pekovic helped out with 18 points and 11 rebounds.
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