Patty Mills came off the bench to score 15 points and Tony Parker added 12 with seven assists for the Spurs, who outscored Cleveland 35-11 in the second quarter to put the contest away.
Marco Belinelli and Tiago Splitter provided 10 points each as San Antonio remained unbeaten at home.
Andrew Bynum led Cleveland with 21 points and Matthew Dellavedova had 14.
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