Deng helped Chicago overcome a poor shooting performance with a key 3-pointer late in the game, boosting the Bulls to a 5-0 record on their home court.
Carlos Boozer contributed a double-double of 12 points and 17 rebounds.
Jimmy Butler (14 points) and Derrick Rose (12) also reached double figures for Chicago.
Charlotte was led by Jeff Taylor with 20 points off the bench.
Gerald Henderson added 16 as the Bobcats dropped a second straight road game.