Lynch supplied 63 yards of total offense on 17 carries and two receptions as the Seahawks (10-1) set a club record for consecutive victories on their home field.
Russell Wilson passed for 230 yards and two TDs on 13-of-18 efficiency and Walter Thurmond III returned an interception for a touchdown for Seattle.
Christian Ponder went 13-of-22 for 129 passing yards with a touchdown but was picked off twice overall before being benched in the fourth quarter by the Vikings (2-8).
Matt Cassel entered and made good on 5-of-13 passes for 78 yards with a touchdown and an interception.
Jarius Wright caught both Minnesota TDs, finishing with three grabs for 69 yards.