Dalton made good on 13-of-27 passes for 93 yards with two interceptions as the AFC North-leading Bengals (7-4) scored 31 points in the second quarter, improving to 5-0 on their home turf.
Cincinnati broke the game open before halftime as Tony Dye returned a blocked punt for a score and Vontaze Burfict found the end zone after a Browns fumble.
Cleveland (4-6) fell for the fourth time in five games as Jason Campbell was intercepted three times. He completed 27-of-56 passes for 248 yards with a touchdown.
Josh Gordon amassed 125 yards with a score on five receptions.