Anderson, who missed the start of the season due to a fractured toe, went 6-of-10 from beyond the arc, scoring 10 straight Pelican points during a 2 1/2-minute span in the first quarter.
Anthony Davis supplied 13 points, nine rebounds and eight blocks.
Former Sixer Jrue Holiday helped out with a double-double of 14 points with 12 assists.
Philadelphia was led by Darius Morris with 20 points.
Tony Wroten, subbing for injured rookie Michael Carter-Williams, added 19 points for the Sixers.