Mason Raymond added a goal and an assist for the Leafs, who bounced back after falling to the Sabres 3-1 Friday.
Nikolai Kulemin recorded his first goal of the season as Toronto broke a three-game losing streak.
James Reimer earned the victory with 33 saves.
Tyler Ennis and Jamie McBain each scored for Buffalo.
Jhonas Enroth turned aside 18-of-22 shots.
Celebrity Breakups and divorces of 2014 [PHOTOS]