Lillard, who went just 1-of-15 from the field in Saturday's victory over Sacramento, provided 14 of his points in the first half and the Blazers turned back a late Pistons rally to claim a third straight win.
Mo Williams chipped in with 17 points off the bench.
Brandon Jennings put in 28 points to spark a comeback try but the Pistons instead fell to their third straight loss.
Andre Drummond supplied 16 points with 16 rebounds and Greg Monroe contributed 19 and eight for Detroit.
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