Griffin scored 14 of his points in the second half as Los Angeles erased a 12-point deficit with a 40-18 surge in the game's later stages.
It was the Clippers' second win over the Rockets in five days -- they also recorded a 137-118 rout of Houston Monday. Los Angeles had dropped two road games in between.
Chandler Parsons registered 23 points and eight rebounds for the Rockets, who fell at home for the second consecutive game.
Dwight Howard ha 21 points and eight rebounds.