Iguodala, who played for the Sixers from 2004 to 2012, buried a career-high seven 3-pointers against his ex-teammates as the Warriors recorded a second straight win.
Stephen Curry contributed a triple-double of 18 points, 12 assists and 10 rebounds, and also made five steals.
David Lee (18 points) and Klay Thompson (15) also reached double figures in the rout.
Rookie Michael Carter-Williams and Evan Turner each provided 18 points for Philadelphia, which had begun the season with three straight victories.
Celebrity Couples of 2014 [PHOTOS]