Lance Stephenson chipped in with 22 points as the Pacers improved to 3-0 for the second time in three years.
The Cavaliers got 17 points and four steals Dion Waiters in their seventh consecutive loss to Indiana.
Kyrie Irving contributed 15 points and five assists for Cleveland.
Notable deaths of 2014 [PHOTOS]
UPI Sports Results for September 19, 2014