Advancing outside the early leaders, the 5-year-old Mizzen Mast mare edged ahead in the final 100 yards and won by 1/2 length. Reneesgotzip, who led most of the way, finished in a dead heat with Tightend Touchdown for second and third. Unbridled's Note was fourth.
Mizdirection ran about 6 1/2 furlongs on the Santa Anita hillside turf course in 1:12.25 -- a relatively moderate time after a very quick early pace.
Jockey Mike Smith notched his 20th Breeders' Cup win, by far the most of any rider in the 30-year history of the event. It was his third Breeders' Cup victory of weekend.
Mizdirection had won four straight races before a fifth-place finish in her last start, the Grade I Just a Gleam Stakes at Belmont Park, when she tried 1 mile over yielding turf.