Alterite finished third in a 1-2-3 sweep for horses who started their season in Europe. Emollient finished fourth, the best showing of any American distaffer in a race often dominated by foreign starters.
Dank won the Grade I Beverly D. at Arlington Park in August in her first U.S. start.
Saturday, she was always close under jockey Ryan Moore. Emollient took the lead around the final turn but Moore kicked Dank into gear and she was quickly in front and none of the others could make up any ground.
The 1 1/4 miles on firm Santa Anita turf took 1:58.73.
Dank, a 4-year-old Dansili mare, had five victories in England before traveling to the United States for the Beverly D. but had not contested a Group 1 race in her native country.
Winning owner James Wigan said he hopes to keep Dank in training.
"I'd love to come back," he said in the winner's circle.
The Breeders' Cup returns to Santa Anita in 2014 for its third straight year at the Southern California oval.