In a rematch of last year's Western Conference finals, the Spurs shot 52 percent from the field and made 11-of-20 from 3-point range to begin their season.
San Antonio is trying to bounce back from a devastating seven-game loss to Miami in last year's championship series, one the Spurs appeared to have wrapped up in Game 6 before a dramatic 3-pointer from Ray Allen with five seconds remaining kept the Heat alive.
Veteran San Antonio center Tim Duncan left the game with a chest contusion, having played just 17 minutes. The team had no immediate word as to the seriousness of the injury.
The Spurs took charge by outscoring Memphis 30-7 in the second period. Tony Allen led the Grizzlies with 15 points.
NBC reportedly holds celebs hostage to Jimmy Fallon's show
Millions of Getty images now available for free via embed tool