The Red Sox closed out the Cardinals in six games, completing a magical season that came one year after Boston finished last in its division with just 69 victories.
Boston roughed up St. Louis starter Michael Wacha, who had won the first four post-season starts of his career and was being counted on by the Cardinals to get them into a deciding Game 7.
Instead, it was Boston's John Lackey who was able to scramble his way out of trouble and bring the Red Sox another in what has become a series of championships.
After having gone 86 years without a World Series triumph, the Red Sox added the 2013 title to the ones they won in 2004 and 2007. Boston and St. Louis have combined to win five of the last 10 World Series.
Both teams put their first two runners on base in the second inning without scoring, but Boston did not let its big chance in the third get away.
Jacoby Ellsbury singled to open the inning and moved to second on a ground out by Dustin Pedroia. David Ortiz was then intentionally walked and Wacha struck out Mike Napoli to give himself a chance to escape the inning.
Wacha, however, hit Jonny Gomes with a pitch to load the bases and Victorino followed by launching a shot high off the wall in left field. All three runners scored to give Boston fans a chance to practice the late-night celebration that was to come.
Boston added four more hits in the fourth inning, including a home run by Stephen Drew on the first pitch of the frame. A double by Ellsbury, another intentional walk to Ortiz and singles by Napoli and Victorino accounted for two more runs and a 6-0 lead.
Lackey, meanwhile, put two runners on in the second, fourth and fifth innings without allowing a run and then gave up three straight hits and a walk in the seventh.
With a run in and the bases loaded, Junichi Tazawa replaced Lackey and got Allen Craig on a ground out to end the inning.
Brandon Workman then pitched a perfect eighth for Boston and Koji Uehara, who had 21 saves during the regular campaign with a 1.09 earned run average, came on in the ninth to retire the final three batters of the baseball season.