Gore finished with 70 yards on 24 carries while Kaepernick threw for 199 yards on 13-of-21 efficiency and added 64 more on the ground as the 49ers (5-2) reeled off a fourth straight victory.
Anquan Boldin led San Francisco's receiving corps with five catches for 74 yards.
The Titans (3-4) dropped a third consecutive game despite a good performance from Jake Locker, who returned from a hip injury to complete 25-of-41 passes for 326 yards, two touchdowns and an interception.
Running back Chris Johnson grabbed one of Locker's scoring strikes, ending with four receptions and nine carries for 110 total yards.
NBC reportedly holds celebs hostage to Jimmy Fallon's show
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